Harding C V
Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Am J Respir Cell Mol Biol. 1993 May;8(5):461-7. doi: 10.1165/ajrcmb/8.5.461.
Antigen processing is the conversion of native antigen molecules into short peptides that can then bind to major histocompatibility complex (MHC) molecules. Class II MHC (MHC-II) molecules target to endocytic compartments, where they bind peptides that are produced by internalization of extracellular antigens and subsequent antigen catabolism. The resulting peptide-MHC complexes are displayed on the surface of antigen-presenting cells for recognition by T cells. Thus, MHC-II molecules first serve as peptide receptors that rescue peptides from total lysosomal degradation and transport them to the plasma membrane; the MHC-II molecules then form a composite peptide-MHC-II determinant that is recognized by the T cell receptor. Recent work has begun to clarify the molecular events and transport mechanisms that govern antigen processing.
抗原加工是将天然抗原分子转化为短肽的过程，这些短肽随后可与主要组织相容性复合体（MHC）分子结合。II类MHC（MHC-II）分子靶向内吞小室，在那里它们结合由细胞外抗原内化和随后的抗原分解代谢产生的肽。产生的肽-MHC复合物展示在抗原呈递细胞表面以供T细胞识别。因此，MHC-II分子首先作为肽受体，从溶酶体的完全降解中拯救肽并将它们转运到质膜；然后MHC-II分子形成一个复合的肽-MHC-II决定簇，被T细胞受体识别。最近的研究开始阐明控制抗原加工的分子事件和转运机制。
