Kirk I R, Carrasco C H, Lawrence D D, Chuang V P, Richli W R, Charnsangavej C, Kavanagh J J, Kudelka A P, Freedman R S, Markowitz A B
Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center 77030.
J Vasc Interv Radiol. 1993 Mar-Apr;4(2):299-304. doi: 10.1016/s1051-0443(93)71864-3.
The authors reviewed their experience with percutaneous placement of catheters into the peritoneal cavity for the administration of intraperitoneal chemotherapy to determine if their approach resulted in a lower complication rate than the reported 12%-16% rate and to demonstrate the technical advantages over surgically placed catheters.
Seventy-six patients with gastrointestinal or gynecologic malignancies underwent 152 procedures during a 20-month period. The catheters were used to deliver antineoplastic agents and, in some patients, to drain ascites. Catheter insertion was performed with local anesthesia and a modified Seldinger technique. A 5-F catheter was used in 89% of procedures; in the remainder, the catheter was of a larger caliber.
The procedure was successful in 145 (95%) instances and failed in seven (5%) attempts because of peritoneal adhesions. The catheters remained in place for less than 2 days in 56%, 2-10 days in 25%, and more than 10 days in 19% of patients. One catheter remained in place for 15 weeks. Complications occurred in seven procedures (5%). Four cases of mild peritonitis responded to a brief course of intravenously administered antibiotics, and severe pain in two patients required premature catheter removal. A single case of inadvertent transcolonic catheter placement occurred without adverse sequelae to the patient.
Intraperitoneal catheterization can be performed with local anesthesia by using a simple technique with a very low complication rate. The catheters can remain in place for prolonged periods without significant risks.
作者回顾了他们经皮将导管置入腹腔进行腹腔内化疗的经验,以确定他们的方法是否能产生低于报道的12%-16%的并发症发生率,并展示相对于手术放置导管的技术优势。
76例胃肠道或妇科恶性肿瘤患者在20个月期间接受了152次操作。导管用于输送抗肿瘤药物,部分患者还用其引流腹水。导管插入采用局部麻醉和改良的Seldinger技术。89%的操作使用5F导管;其余操作使用的导管口径更大。
145例(95%)操作成功,7例(5%)因腹膜粘连失败。56%的患者导管留置时间不到2天,25%的患者为2-10天,19%的患者超过10天。一根导管留置了15周。7例操作(5%)出现并发症。4例轻度腹膜炎经短期静脉应用抗生素后好转,2例患者的严重疼痛需要提前拔除导管。发生1例意外经结肠放置导管的情况,但对患者无不良后果。
腹腔内导管置入可在局部麻醉下通过简单技术进行,并发症发生率极低。导管可长时间留置而无明显风险。