Chen D, Håkanson R, Sundler F
Department of Pharmacology, University of Lund, Sweden.
Cell Tissue Res. 1993 Apr;272(1):71-7. doi: 10.1007/BF00323572.
The histamine-producing enterochromaffin-like (ECL) cells in the acid-producing portion of the rat stomach responded to long-standing hypergastrinemia (omeprazole treatment daily for 8-10 weeks) with hypertrophy (and hyperplasia) and with a reduced number of granules and vesicles per unit cytoplasm. There was a reduction in the ratio of electron-dense granules versus vesicles and an increase in the profile diameter of the vesicles. Also, portacaval shunting (PCS) induced changes in the ECL cells, manifesting (i) as an increase in cell number and size, and (ii) as a reduced number of granules and vesicles per unit area. The cytoplasmic granules and vesicle profiles were enlarged, and the ratio of granules versus vesicles was reduced. The combination of PCS and long-standing hypergastrinemia (omeprazole treatment) produced a greatly enhanced ECL cell hypertrophy (and hyperplasia) and a marked reduction in the number of granules. The ratio of granules versus vesicles was markedly reduced while the profile diameters of both granules and vesicles were increased. The relative predominance of very large vesicles (vacuoles) was a prominent feature of the ECL cells in these rats.
大鼠胃产酸部位分泌组胺的肠嗜铬样（ECL）细胞对长期高胃泌素血症（每日用奥美拉唑治疗8 - 10周）的反应是肥大（和增生），且单位细胞质内颗粒和小泡数量减少。电子致密颗粒与小泡的比例降低，小泡的轮廓直径增加。此外，门腔分流术（PCS）引起ECL细胞变化，表现为：（i）细胞数量和大小增加；（ii）单位面积内颗粒和小泡数量减少。细胞质颗粒和小泡轮廓增大，颗粒与小泡的比例降低。PCS与长期高胃泌素血症（奥美拉唑治疗）相结合，使ECL细胞肥大（和增生）显著增强，颗粒数量明显减少。颗粒与小泡的比例显著降低，而颗粒和小泡的轮廓直径均增加。非常大的小泡（空泡）相对占优势是这些大鼠ECL细胞的一个突出特征。
