Genovese A, Spadaro G, Marone G
Department of Medicine, Second School of Medicine, University of Naples Federico II, Italy.
Clin Exp Dermatol. 1993 Mar;18(2):159-61. doi: 10.1111/j.1365-2230.1993.tb01002.x.
This report describes a case of livedo reticularis associated with increased titres of anticardiolipin antibodies (aCL) in a patient with systemic lupus erythematosus. A 38-year-old woman presented with fever, malaise, arthritis and livedo reticularis in a severe form. Antibodies to native DNA and an increased level of aCL were found. A significant positive correlation exists between livedo reticularis and elevated serum antiphospholipid activity in patients with systemic lupus erythematosus. aCL are shown to play a possible pathogenetic role in thrombotic events. This suggests that thrombosis is the underlying cause of livedo in these patients. A biopsy performed in a patient at the site where livedo was most marked showed no evidence of thrombi. It is postulated that the mechanism of livedo in lupus patients with aCL consists of both thrombosis and dysfunction in the regulation of the tone of the peripheral vascular bed.
本报告描述了一名系统性红斑狼疮患者出现网状青斑且抗心磷脂抗体（aCL）滴度升高的病例。一名38岁女性表现为发热、不适、关节炎及严重的网状青斑。发现了抗双链DNA抗体及aCL水平升高。系统性红斑狼疮患者的网状青斑与血清抗磷脂活性升高之间存在显著正相关。aCL在血栓形成事件中可能发挥致病作用。这表明血栓形成是这些患者出现网状青斑的根本原因。在网状青斑最明显部位对一名患者进行活检，未发现血栓证据。据推测，伴有aCL的狼疮患者出现网状青斑的机制包括血栓形成及外周血管床张力调节功能障碍。
