Weinstein C, Miller M H, Axtens R, Buchanan R, Littlejohn G O
Arch Dermatol. 1987 May;123(5):596-600.
Seventy-eight consecutive patients with systemic lupus erythematosus were assessed for the presence of livedo reticularis. The possible association of livedo reticularis with other clinical and laboratory features including anticardiolipin antibodies was explored. Thirty-eight patients had livedo reticularis. Four cases were severe, 11 moderate, and 23 mild. There was a statistically significant association between the combined moderate and severe livedo reticularis group and elevated levels of anticardiolipin antibodies. The recognized association of anticardiolipin antibodies with thrombotic events suggests a possible pathogenetic role. The presence or history of central nervous system disease, renal disease, vasculitis, or lupus inhibitor was significantly associated with the moderate and severe livedo reticularis group. Livedo reticularis may be a cutaneous marker for the later development of important systemic events in systemic lupus erythematosus.
对78例连续性系统性红斑狼疮患者进行网状青斑检查。探讨了网状青斑与包括抗心磷脂抗体在内的其他临床和实验室特征之间的可能关联。38例患者有网状青斑。4例严重，11例中度，23例轻度。中度和重度网状青斑合并组与抗心磷脂抗体水平升高之间存在统计学显著关联。抗心磷脂抗体与血栓形成事件之间已被认可的关联提示了一种可能的致病作用。中枢神经系统疾病、肾脏疾病、血管炎或狼疮抑制剂的存在或病史与中度和重度网状青斑组显著相关。网状青斑可能是系统性红斑狼疮中重要全身性事件后期发生的皮肤标志物。
