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Identification of phytanoyl-CoA ligase as a distinct acyl-CoA ligase in peroxisomes from cultured human skin fibroblasts.

作者信息

Pahan K, Cofer J, Baliga P, Singh I

机构信息

Department of Pediatrics, Medical University of South Carolina, Charleston 29425.

出版信息

FEBS Lett. 1993 May 10;322(2):101-4. doi: 10.1016/0014-5793(93)81546-c.

DOI:10.1016/0014-5793(93)81546-c
PMID:8482375
Abstract

Phytanic acid accumulates in excessive amounts in Refsum disease, a rare neurological disorder, due to a defect in its alpha-oxidation enzyme system in peroxisomes. The activation of phytanic acid to phytanoyl-CoA by phytanoyl-CoA ligase is a prerequisite for its alpha-oxidation. The studies described in this manuscript report that phytanoyl-CoA ligase in peroxisomes is an enzyme distinct from the previously reported acyl-CoA ligases.

摘要

相似文献

1
Identification of phytanoyl-CoA ligase as a distinct acyl-CoA ligase in peroxisomes from cultured human skin fibroblasts.
FEBS Lett. 1993 May 10;322(2):101-4. doi: 10.1016/0014-5793(93)81546-c.
2
Phytanic acid must be activated to phytanoyl-CoA prior to its alpha-oxidation in rat liver peroxisomes.植烷酸在大鼠肝脏过氧化物酶体中进行α-氧化之前，必须先被激活为植烷酰辅酶A。
Biochim Biophys Acta. 1994 Oct 6;1214(3):288-94. doi: 10.1016/0005-2760(94)90075-2.
3
Phytanic acid activation in rat liver peroxisomes is catalyzed by long-chain acyl-CoA synthetase.大鼠肝脏过氧化物酶体中的植烷酸激活由长链酰基辅酶A合成酶催化。
J Lipid Res. 1996 Nov;37(11):2288-95.
4
Purification of peroxisomes and subcellular distribution of enzyme activities for activation and oxidation of very-long-chain fatty acids in rat brain.大鼠脑中过氧化物酶体的纯化以及超长链脂肪酸激活和氧化相关酶活性的亚细胞分布
Biochim Biophys Acta. 1993 Sep 29;1170(1):44-52. doi: 10.1016/0005-2760(93)90174-8.
5
Phytanic acid oxidation: topographical localization of phytanoyl-CoA ligase and transport of phytanic acid into human peroxisomes.植烷酸氧化：植烷酰辅酶A连接酶的拓扑定位及植烷酸向人过氧化物酶体的转运
J Lipid Res. 1995 May;36(5):986-97.
6
Refsum disease: a defect in the alpha-oxidation of phytanic acid in peroxisomes.雷夫叙姆病：过氧化物酶体中植烷酸α-氧化缺陷。
J Lipid Res. 1993 Oct;34(10):1755-64.
7
Phytanoyl-CoA ligase activity in rat liver.
Biochem Int. 1986 Jul;13(1):123-30.
8
Acyl-CoA synthetase and the peroxisomal enzymes of beta-oxidation in human liver. Quantitative analysis of their subcellular localization.人肝脏中的酰基辅酶A合成酶与β-氧化的过氧化物酶体酶。其亚细胞定位的定量分析。
Biochem J. 1984 Dec 15;224(3):709-20. doi: 10.1042/bj2240709.
9
Topographical localization of peroxisomal acyl-CoA ligases: differential localization of palmitoyl-CoA and lignoceroyl-CoA ligases.过氧化物酶体酰基辅酶A连接酶的定位：棕榈酰辅酶A和木蜡酰辅酶A连接酶的差异定位
Biochemistry. 1990 Apr 24;29(16):3981-6. doi: 10.1021/bi00468a027.
10
Cellular oxidation of lignoceric acid is regulated by the subcellular localization of lignoceroyl-CoA ligases.二十四烷酸的细胞氧化受二十四烷酰辅酶A连接酶的亚细胞定位调控。
J Lipid Res. 1990 Apr;31(4):583-95.

引用本文的文献

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Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease.神经元脂质代谢：健康与疾病中驱动功能结果的多种途径
Front Mol Neurosci. 2018 Jan 23;11:10. doi: 10.3389/fnmol.2018.00010. eCollection 2018.
2
Biochemistry of peroxisomes in health and disease.健康与疾病状态下过氧化物酶体的生物化学
Mol Cell Biochem. 1997 Feb;167(1-2):1-29. doi: 10.1023/a:1006883229684.