Endothelin-1 stimulated phospholipase D in A10 vascular smooth muscle derived cells is dependent on tyrosine kinase. Evidence for involvement in stimulation of mitogenesis.
作者信息
Wilkes L C, Patel V, Purkiss J R, Boarder M R
机构信息
Department of Pharmacology and Therapeutics, University of Leicester, UK.
出版信息
FEBS Lett. 1993 May 10;322(2):147-50. doi: 10.1016/0014-5793(93)81556-f.
PMID:8482382
Abstract
The mechanism whereby endothelin stimulates mitogenesis of vascular smooth muscle cells is not understood. Here we show that endothelin-1 stimulates phospholipase D by a protein kinase C and tyrosine kinase dependent mechanism, and present evidence that implicate the phosphatidic acid formed by phospholipase D in the mitogenic response.
摘要
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