Breier F, Hobisch G, Groz S
II. Universitäts Hautklinik Wien.
Hautarzt. 1993 Apr;44(4):229-31.
A 64-year-old woman complained of reddish plaques that had suddenly appeared on her upper arms and trunk. Histological investigation revealed perivascular distribution of a neutrophilic infiltrate in the upper and mid-dermis; direct immunofluorescence showed deposits of C3 and fibrin in and around the vessels. Laboratory values in the blood, X-ray of the head and fine-needle biopsy of the hip showed the typical pattern of multiple myeloma. After chemotherapy the dermatological lesions improved rapidly, and the plasmocytoma reached remission stage. The diagnosis of Sweet's syndrome was established on the basis of the clinical and histological changes and the improvement observed after steroid therapy. The coincidence with plasmocytoma confirms the interpretation of Sweet disease as a paraneoplastic syndrome.
一名64岁女性主诉其上臂和躯干突然出现红色斑块。组织学检查显示真皮上部和中部有嗜中性粒细胞浸润呈血管周围分布；直接免疫荧光显示血管内及周围有C3和纤维蛋白沉积。血液实验室检查值、头部X线检查及髋部细针活检显示为多发性骨髓瘤的典型表现。化疗后皮肤病损迅速改善，浆细胞瘤进入缓解期。根据临床和组织学变化以及激素治疗后观察到的改善情况，确诊为Sweet综合征。与浆细胞瘤的并存证实了将Sweet病解释为副肿瘤综合征的观点。
