de Souza F M
St. Michael's Hospital, Toronto, Ontario.
Laryngoscope. 1993 May;103(5):477-93. doi: 10.1288/00005537-199305000-00001.
Clinically apparent thyroid nodules affect 4% to 7% of the population in North America. Malignant neoplasms of the thyroid comprise only about 1% of all cancers and are found in only 20% of patients undergoing thyroid surgery for suspected thyroid carcinoma. A follicular neoplasm of the thyroid is the most common histologic finding. During surgery, using frozen-section techniques, it is often difficult to distinguish between a benign and malignant lesion. The diagnosis may be deferred following intraoperative frozen-section examination of tissue or changed on evaluation of embedded tissue. In this series of 1224 thyroidectomies from 1976 to 1990, the pathology data from thyroidectomy surgical specimens submitted to tissue analysis were evaluated. It was found that subtotal thyroidectomy was effective in the management of the follicular neoplasm. This approach significantly reduced the morbidity and complications of patients undergoing thyroidectomy.
临床上可触及的甲状腺结节在北美人群中的发生率为4%至7%。甲状腺恶性肿瘤仅占所有癌症的约1%，且仅在20%因疑似甲状腺癌而接受甲状腺手术的患者中被发现。甲状腺滤泡性肿瘤是最常见的组织学表现。在手术过程中，使用冰冻切片技术，往往难以区分良性和恶性病变。诊断可能会在术中对组织进行冰冻切片检查后延迟，或者在对包埋组织进行评估时发生改变。在这组1976年至1990年的1224例甲状腺切除术中，对提交进行组织分析的甲状腺切除手术标本的病理数据进行了评估。结果发现，甲状腺次全切除术对滤泡性肿瘤的治疗有效。这种方法显著降低了接受甲状腺切除术患者的发病率和并发症。
