Patt B S, Close L G, Vuitch F
Department of Otorhinolaryngology, University of Texas Southwestern Medical Center, Dallas 75235-9035.
Laryngoscope. 1993 May;103(5):498-502. doi: 10.1288/00005537-199305000-00003.
A histopathologic analysis of regional lymph node specimens in 48 patients with previously untreated squamous cell carcinoma of the larynx was performed to determine which parameters, if any, correlated with 3-year patient survival. The presence of sinus histiocytosis in lymph nodes containing metastatic squamous cell carcinoma was statistically related to survival (P < .007). Multivariate analysis confirmed the independent significance of this variable compared to tumor stage, nodal status, and extracapsular spread from lymph nodes. Previous studies have linked improved survival with an active immunologic response in head and neck cancer patients. However, few studies have examined a homogeneous group of patients who all underwent the same type of treatment. This study's findings support the concept that an active immunologic response in lymph nodes has prognostic significance in squamous cell carcinoma of the larynx.
对48例未经治疗的喉鳞状细胞癌患者的区域淋巴结标本进行了组织病理学分析，以确定哪些参数（如果有的话）与患者3年生存率相关。在含有转移性鳞状细胞癌的淋巴结中，窦组织细胞增生的存在与生存率具有统计学相关性（P <.007）。多变量分析证实，与肿瘤分期、淋巴结状态和淋巴结包膜外扩散相比，该变量具有独立的意义。先前的研究将头颈癌患者生存率的提高与活跃的免疫反应联系起来。然而，很少有研究对所有接受相同类型治疗的同质患者群体进行过研究。本研究结果支持这样一种概念，即淋巴结中的活跃免疫反应在喉鳞状细胞癌中具有预后意义。
