从海葵中分离出新型生物活性神经肽<Glu-Asn-Phe-His-Leu-Arg-Pro-NH2（Antho-RPamide II）。

Isolation of <Glu-Asn-Phe-His-Leu-Arg-Pro-NH2 (Antho-RPamide II), a novel, biologically active neuropeptide from sea anemones.

作者信息

Carstensen K, McFarlane I D, Rinehart K L, Hudman D, Sun F, Grimmelikhuijzen C J

机构信息

Center for Molecular Neurobiology (ZMNH), University of Hamburg, Germany.

出版信息

Peptides. 1993 Mar-Apr;14(2):131-5. doi: 10.1016/0196-9781(93)90020-h.

DOI:10.1016/0196-9781(93)90020-h

Abstract

Using a radioimmunoassay against the C-terminal sequence Arg-Pro-NH2 (RPamide) we have isolated the neuropeptide <Glu-Asn-Phe-His-Leu-Arg-Pro-NH2 (Antho-RPamide II) from extracts of the sea anemone Anthopleura elegantissima. Addition of low concentrations of Antho-RPamide II to a tentacle preparation of sea anemones inhibited the spontaneous, rhythmic contractions, suggesting that the peptide is a neurotransmitter or neuromodulator.

摘要

我们使用针对C末端序列精氨酸 - 脯氨酸 - 氨基（RPamide）的放射免疫分析法，从海葵优美列指海葵（Anthopleura elegantissima）的提取物中分离出了神经肽<谷氨酸 - 天冬酰胺 - 苯丙氨酸 - 组氨酸 - 亮氨酸 - 精氨酸 - 脯氨酸 - 氨基（Antho - RPamide II）。向海葵触手制剂中添加低浓度的Antho - RPamide II会抑制自发的节律性收缩，这表明该肽是一种神经递质或神经调节剂。

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