Rioux F, Paré D
Centre de Recherche, Hôtel-Dieu de Québec, Canada.
Peptides. 1993 Mar-Apr;14(2):227-34. doi: 10.1016/0196-9781(93)90034-e.
The intravenous (IV) infusion of neurotensin (NT) in anesthetized guinea pigs was found to elicit dose-dependent increases of systemic blood pressure (BP) and of heart rate (HR), accompanied by abdominal motor responses consisting in transient, twitch-like contractions of the abdominal wall (TAWC), and a slowly developing, relatively sustained increase of the basal abdominal wall tension (AWT). The TAWC responses were inhibited in animals pretreated with pancuronium, morphine, clonidine, and CP-96,345 [a neurokinin (NK) antagonist], were potentiated by naloxone, but were not modified by atropine or prior (30 s) intraperitoneal (IP) injection of lidocaine. The BP increases caused by IV NT were reduced by clonidine and by IP lidocaine only. The HR increases were attenuated by morphine and clonidine only. Increases of the basal AWT were resistant to all drug treatments and were attributed to a passive stretch of the abdominal wall caused by cecal distension. No defecation was observed in any of the animals given IV NT. These results were interpreted as an indication that the pressor and TAWC responses to IV NT represent an integrated nociceptive response likely to be triggered in part by NT-induced activation of abdominal visceral afferents. A NK acting through NK-1 receptors may participate in TAWC responses to IV NT.
在麻醉的豚鼠中静脉输注神经降压素（NT），发现会引起全身血压（BP）和心率（HR）呈剂量依赖性增加，同时伴有腹部运动反应，包括腹壁短暂的抽搐样收缩（TAWC）以及腹壁基础张力（AWT）缓慢发展且相对持续的增加。用泮库溴铵、吗啡、可乐定和CP - 96,345（一种神经激肽（NK）拮抗剂）预处理的动物，TAWC反应受到抑制，纳洛酮可增强该反应，但阿托品或预先（30秒）腹腔注射利多卡因对其无影响。静脉注射NT引起的血压升高仅被可乐定和腹腔注射利多卡因降低。心率增加仅被吗啡和可乐定减弱。基础AWT的增加对所有药物治疗均有抵抗，这归因于盲肠扩张引起的腹壁被动伸展。在任何接受静脉注射NT的动物中均未观察到排便。这些结果被解释为表明对静脉注射NT的升压和TAWC反应代表一种可能部分由NT诱导的腹部内脏传入神经激活触发的综合伤害性反应。通过NK - 1受体起作用的NK可能参与对静脉注射NT的TAWC反应。
