Segatore M, Way C
SCI Nurs. 1993 Mar;10(1):8-14.
The assumption that maximal spinal cord injury occurs at the moment of trauma is being challenged by emerging evidence that cellular injury continues after the acute event. Efforts are now being made to alter the course of secondary injury in order to improve the functional outcome of survivors. Methylprednisolone has been studied in two clinical trials--the National Acute Spinal Cord Injury Studies (NASCIS I, NASCIS II)--to determine its ability to protect compromised but viable cellular elements, and thus improve outcome. The purpose of this paper is threefold: (1) to explore the putative mechanisms of secondary spinal cord injury, (2) to examine the role of methylprednisolone in spinal cord injury, and (3) to discuss the findings and clinical implications of NASCIS I and NASCIS II.
创伤时脊髓损伤即达最大限度这一假设正受到新出现证据的挑战，这些证据表明在急性损伤事件之后细胞损伤仍在继续。目前正在努力改变继发性损伤的进程，以改善幸存者的功能预后。甲基强的松龙已在两项临床试验——国家急性脊髓损伤研究（NASCIS I、NASCIS II）中进行研究，以确定其保护受损但仍存活的细胞成分从而改善预后的能力。本文的目的有三个：（1）探讨继发性脊髓损伤的可能机制；（2）研究甲基强的松龙在脊髓损伤中的作用；（3）讨论NASCIS I和NASCIS II的研究结果及临床意义。
