Mori S, Kobayashi S, Miki H, Hirakawa E, Haba R, Ohmori M, Miyaguchi M
First Department of Pathology, Kagawa Medical School, Japan.
Acta Pathol Jpn. 1993 Mar;43(3):130-4. doi: 10.1111/j.1440-1827.1993.tb01121.x.
A case of extracranial meningioma in the parapharyngeal space is reported. A 24 year old woman presented with swelling and tenderness of the parapharyngeal region. A tumor was palpable in this region, and the tumor was surgically removed. Macroscopically the tumor occurred from the portion between the axis and atlas. Histologically the tumor cells, which had oval nuclei and a slightly eosinophilic cytoplasm, proliferated in fibrous connective tissues to form small nests. As the cell borders were not clear, the tumor structure appeared to be syncytium-like. Immunohistochemically the tumor cells were positive for anti-vimentin antibodies, anti-S-100 protein antibodies and anti-epithelial membrane antigen (EMA) antibodies in part. Electron microscopically the tumor cells had complex interdigitations of their adjacent plasma membranes. These were studded with many desmosomes. Bundles of intermediate filaments were visible in the cytoplasm. On the basis of the clinical, histological, immunohistochemical and electron microscopical features, the tumor was diagnosed as extracranial meningotheliomatous meningioma. The parapharyngeal space is an extremely rare location for extracranial meningioma, and our case is the first in Japan as far as we know.
本文报道了1例发生于咽旁间隙的颅外脑膜瘤。一名24岁女性患者，表现为咽旁区域肿胀和压痛。该区域可触及一个肿瘤，遂行手术切除。大体观察，肿瘤起源于枢椎和寰椎之间的部分。组织学检查显示，肿瘤细胞呈椭圆形核，胞质轻度嗜酸性，在纤维结缔组织中增殖形成小巢状。由于细胞边界不清晰，肿瘤结构呈合胞体样。免疫组化检查显示，肿瘤细胞部分抗波形蛋白抗体、抗S-100蛋白抗体和抗上皮膜抗原（EMA）抗体呈阳性。电镜观察显示，肿瘤细胞相邻质膜有复杂的指状交叉，其上有许多桥粒。胞质内可见中间丝束。根据临床、组织学、免疫组化和电镜特征，该肿瘤被诊断为颅外脑膜皮型脑膜瘤。咽旁间隙是颅外脑膜瘤极为罕见的发生部位，据我们所知，本例是日本首例。
