Shemesh Z, Attias J, Ornan M, Shapira N, Shahar A
Institute of Noise Hazards Research and Evoked Potentials Laboratory, IDF, Chaim-Sheba Medical Center, Ramat-Gan, Israel.
Am J Otolaryngol. 1993 Mar-Apr;14(2):94-9. doi: 10.1016/0196-0709(93)90046-a.
This study examines the incidence of vitamin B12 deficiency in three groups of noise-exposed subjects: patients with chronic tinnitus and noise-induced hearing loss (NIHL), patients with NIHL only, and subjects demonstrating normal hearing.
A group of 113 army personnel exposed to military noise was studied. The mean age was 39 years. Chronic tinnitus and NIHL existed in 57 subjects. NIHL alone was observed in 29 subjects, and 27 subjects had normal audiograms. All subjects were queried about noise exposure and dietary habits. Vitamin B12 serum levels were measured.
Patients with tinnitus and NIHL exhibited vitamin B12 deficiency in 47% of cases (blood levels < or = 250 pg/mL). This was significantly more (P < .023) compared with NIHL and normal subjects who exhibited vitamin B12 deficiency in 27% and 19%, respectively.
These observations suggest a relationship between vitamin B12 deficiency and dysfunction of the auditory pathway. Some improvement in tinnitus and associated complaints were observed in 12 patients following vitamin B12 replacement therapy. The authors recommend that routine vitamin B12 serum levels be determined when evaluating patients for chronic tinnitus.
本研究调查了三组噪声暴露受试者中维生素B12缺乏症的发生率：患有慢性耳鸣和噪声性听力损失（NIHL）的患者、仅患有NIHL的患者以及听力正常的受试者。
对一组113名暴露于军事噪声的军队人员进行了研究。平均年龄为39岁。57名受试者存在慢性耳鸣和NIHL。仅观察到29名受试者患有NIHL，27名受试者听力图正常。所有受试者均被询问了噪声暴露情况和饮食习惯。测量了血清维生素B12水平。
耳鸣和NIHL患者中47%的病例出现维生素B12缺乏（血药浓度≤250 pg/mL）。与NIHL患者和正常受试者相比，这一比例显著更高（P<0.023），NIHL患者和正常受试者中维生素B12缺乏的比例分别为27%和19%。
这些观察结果表明维生素B12缺乏与听觉通路功能障碍之间存在关联。12名患者在接受维生素B12替代治疗后耳鸣及相关症状有所改善。作者建议在评估慢性耳鸣患者时常规测定血清维生素B12水平。
