Werner C, Hoffman W E, Kochs E, Schulte am Esch J, Albrecht R F
Humana Hospital Michael Reese, Chicago, Illinois.
Anesth Analg. 1993 May;76(5):971-5. doi: 10.1213/00000539-199305000-00009.
The effects of low and high doses of propofol on global cerebral blood flow (CBF) and spinal cord blood flow (SCBF) as a function of mean arterial blood pressure were investigated. CBF and SCBF during propofol infusion were compared to the levels in rats anesthetized with nitrous oxide (N2O) and fentanyl. Rats in the fentanyl/N2O group (control, n = 13) received 70% N2O in O2 plus fentanyl (bolus: 10 micrograms/kg; infusion: 25 micrograms.kg-1 x h-1). Rats in the low-dose propofol group (n = 10) received 30% O2 in air and propofol infusion (0.5 mg.kg-1 x min-1). Rats in the high-dose propofol group (n = 8) received 30% O2 in air and propofol infusion (2.0 mg.kg-1 x min-1). Blood flow autoregulation was tested by manipulating the mean arterial blood pressure with phenylephrine infusion or trimethaphan infusion and blood withdrawal by measuring CBF and SCBF using radioactive microspheres. Arterial blood gases, pHa, and skull temperature were controlled. Cerebral and spinal cord vasculature showed autoregulation in all treatment groups with a pressure range of 50-140 mm Hg. Within this pressure range, when compared to fentanyl/N2O, propofol decreased cortical CBF 60% (P < 0.001), subcortical CBF 40% (P < 0.001), midbrain blood flow 30% (P < 0.001), and SCBF 20% (P < 0.05). These results indicate that propofol maintains CBF and SCBF autoregulation.
研究了低剂量和高剂量丙泊酚对作为平均动脉血压函数的全脑血流量（CBF）和脊髓血流量（SCBF）的影响。将丙泊酚输注期间的CBF和SCBF与用氧化亚氮（N2O）和芬太尼麻醉的大鼠中的水平进行比较。芬太尼/N2O组（对照组，n = 13）的大鼠接受O2中70%的N2O加芬太尼（推注：10微克/千克；输注：25微克·千克-1×小时-1）。低剂量丙泊酚组（n = 10）的大鼠接受空气中30%的O2和丙泊酚输注（0.5毫克·千克-1×分钟-1）。高剂量丙泊酚组（n = 8）的大鼠接受空气中30%的O2和丙泊酚输注（2.0毫克·千克-1×分钟-1）。通过用去氧肾上腺素输注或三甲噻方输注操纵平均动脉血压并通过使用放射性微球测量CBF和SCBF来进行血流自身调节测试。控制动脉血气、动脉血pH值（pHa）和颅骨温度。在所有治疗组中，脑和脊髓血管系统在50-140毫米汞柱的压力范围内显示出自身调节。在该压力范围内，与芬太尼/N2O相比，丙泊酚使皮质CBF降低60%（P < 0.001），皮质下CBF降低40%（P < 0.001），中脑血流量降低30%（P < 0.001），SCBF降低20%（P < 0.05）。这些结果表明丙泊酚维持CBF和SCBF自身调节。
