Sano T, Patel P M, Drummond J C, Cole D J
Department of Anesthesiology, University of California, San Diego.
Anesth Analg. 1993 May;76(5):990-7. doi: 10.1213/00000539-199305000-00013.
We evaluated the effect of etomidate, thiopental, and isoflurane on ischemic neuronal injury in rats. Control group animals received 1.2% isoflurane. The animals in the etomidate and thiopental groups received an infusion of either etomidate or thiopental until electroencephalographic (EEG) burst-suppression was attained. In the fourth group, the isoflurane concentration was increased to 3% (sufficient to produce EEG burst-suppression). Forebrain ischemia was induced by bilateral carotid artery occlusion with simultaneous hypotension for 10 min. Three days after ischemia, two blinded observers evaluated neuronal injury in coronal brain sections stained with hematoxylin and eosin. Injury to the ventral CA1 of the hippocampus was less in the etomidate group than in the control group. Injury to the entorhinal cortex was less in the thiopental group than in the control group. Histopathologic outcome in animals anesthetized with 1.2% isoflurane and 3% isoflurane was not different. Although these data indicate that etomidate and thiopental might reduce ischemic injury in some structures, the magnitude of the protective effects observed was small.
我们评估了依托咪酯、硫喷妥钠和异氟烷对大鼠缺血性神经元损伤的影响。对照组动物接受1.2%的异氟烷。依托咪酯组和硫喷妥钠组的动物接受依托咪酯或硫喷妥钠输注，直至达到脑电图（EEG）爆发抑制。在第四组中，异氟烷浓度增加到3%（足以产生EEG爆发抑制）。通过双侧颈动脉闭塞并同时低血压10分钟诱导前脑缺血。缺血三天后，两名盲法观察者评估苏木精和伊红染色的冠状脑切片中的神经元损伤。依托咪酯组海马腹侧CA1的损伤小于对照组。硫喷妥钠组内嗅皮质的损伤小于对照组。用1.2%异氟烷和3%异氟烷麻醉的动物的组织病理学结果没有差异。尽管这些数据表明依托咪酯和硫喷妥钠可能会减少某些结构中的缺血性损伤，但观察到的保护作用程度较小。
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