吸入性麻醉剂作为缺血性脑损伤的神经保护剂或化学预处理剂
Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain.
作者信息
Kitano Hideto, Kirsch Jeffrey R, Hurn Patricia D, Murphy Stephanie J
机构信息
Department of Anesthesiology and Peri-Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA.
出版信息
J Cereb Blood Flow Metab. 2007 Jun;27(6):1108-28. doi: 10.1038/sj.jcbfm.9600410. Epub 2006 Oct 18.
Abstract
This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and challenges of past and current research in this area will be addressed before reviewing experimental and clinical studies evaluating the effects of inhalational anesthetics before and during cerebral ischemia. Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed.
摘要
本综述将聚焦于脑缺血期间吸入性麻醉药的神经保护作用以及缺血性脑损伤前的吸入性麻醉药预处理。在回顾评估吸入性麻醉药在脑缺血之前和期间作用效果的实验和临床研究之前，将探讨该领域过去和当前研究的局限性与挑战。还将研究挥发性麻醉药神经保护和预处理的潜在机制。最后，将简要讨论吸入性麻醉药与缺血性脑损伤的未来研究方向。
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