Cervantes C C, Brown M P, Gronwall R, Merritt K
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136.
Am J Vet Res. 1993 Apr;54(4):573-5.
Each of 5 healthy mares was given 5 consecutive IM injections of ceftiofur sodium (2 mg/kg of body weight; 50 mg/ml) at 12-hour intervals. Ceftiofur concentrations were measured serially in serum, synovial fluid, peritoneal fluid, and urine, and were measured in CSF and endometrial tissue after the fifth dose. Mean elimination rate constant was 0.354 +/- 0.101 h-1 and elimination half-life was 2.49 +/- 0.49 hour. Mean serum ceftiofur concentrations peaked approximately 1 hour after each injection. The highest mean ceftiofur concentration was 5.09 micrograms/ml at 1 hour after the fifth dose for serum, 3.02 micrograms/ml at 2 hours after the fifth dose for synovial fluid, and 3.23 micrograms/ml at 4 hours after the fifth dose for peritoneal fluid. Mean urine concentrations reached 15.72 micrograms/ml at 1 hour after the fifth dose. Ceftiofur was not detected in CSF or endometrial tissue. None of the mares had adverse reactions to the drug.
给5匹健康母马每匹连续5次肌肉注射头孢噻呋钠（2毫克/千克体重；50毫克/毫升），间隔12小时。连续测定血清、滑液、腹腔液和尿液中的头孢噻呋浓度，并在第5次给药后测定脑脊液和子宫内膜组织中的浓度。平均消除速率常数为0.354±0.101小时-1，消除半衰期为2.49±0.49小时。每次注射后，血清中头孢噻呋平均浓度约在1小时达到峰值。第5次给药后1小时血清中头孢噻呋最高平均浓度为5.09微克/毫升，第5次给药后2小时滑液中为3.02微克/毫升，第5次给药后4小时腹腔液中为3.23微克/毫升。第5次给药后1小时尿液平均浓度达到15.72微克/毫升。脑脊液和子宫内膜组织中未检测到头孢噻呋。所有母马对该药物均无不良反应。
