Lauersen N H, Wilson K H
Am J Obstet Gynecol. 1977 Apr 1;127(7):784-7. doi: 10.1016/0002-9378(77)90258-7.
Abortion was successfully induced by intravaginal insertion of a silicone rubber device impregnated with an 0.5% concentration of 15(S)-15-methyl-prostaglandin F2alpha methyl ester in 20 of 25 patients by prostaglandin alone and in an additional three patients by prostaglandin with a concomitant oxytocin infusion. The mean abortion time for the 23 successful abortions was 15.46 hours. Uterine activity was monitored in six patients and uterine response to the vaginal insertion of the prostaglandin-impregnated device was characterized by a gradual rise in amplitude of contractions and intrauterine baseline tonus accompanied by a rapid increase in the frequency of contractions. Induction of abortion by intravaginal administration of a silicone rubber device impregnated with prostaglandin eliminates the hazards associated with intra-amniotic instillation and offers the advantage of a single administration with the option of reversibility if a patient should be hypersensitive to the drug.
通过阴道插入浸有0.5%浓度的15(S)-15-甲基前列腺素F2α甲酯的硅橡胶装置，25例患者中有20例仅用前列腺素成功引产，另有3例患者在使用前列腺素的同时静脉滴注催产素成功引产。23例成功引产的平均引产时间为15.46小时。对6例患者的子宫活动进行了监测，阴道插入浸有前列腺素的装置后子宫的反应特点是宫缩幅度和子宫内基线张力逐渐升高，同时宫缩频率迅速增加。通过阴道给药浸有前列腺素的硅橡胶装置引产消除了羊膜腔内注射相关的风险，并且具有单次给药的优势，如果患者对药物过敏还可以选择可逆性。
