Ruiz-Velasco V, Arceo J R, Armesto A
Hospital de Gineco Obstetricia Centro Médico La Raza, IMSS, Mexico City, Mexico.
Int J Fertil Menopausal Stud. 1993 Jan-Feb;38(1):22-7.
The relationship between endometriosis and infertility is observed frequently. Patients with both conditions require a conservative approach to their management. Since hormonal therapy is one of those approaches, we sought to compare the efficacy of Danazol and Gestrinone in 80 infertile patients (48 and 32, respectively). Therapy lasted 6 months in both treatment groups, and all patients studied had laboratory tests performed and were clinically evaluated and classified through laparoscopy before and after therapy. The improvement of symptoms and favorable follow-up were similar with both treatments. The reestablishment of menstrual patterns and fertility were also nearly alike in both groups. However, Gestrinone was associated with fewer secondary effects and is easier to administer than Danazol. We conclude that Gestrinone is a useful medication in the management of the infertile patient with endometriosis.
子宫内膜异位症与不孕症之间的关联屡见不鲜。同时患有这两种病症的患者需要采取保守的治疗方法。鉴于激素疗法是其中一种治疗方法，我们试图比较达那唑和孕三烯酮对80例不孕患者（分别为48例和32例）的疗效。两个治疗组的治疗均持续6个月，所有研究对象在治疗前后均进行了实验室检查，并通过腹腔镜检查进行了临床评估和分类。两种治疗方法在症状改善和良好随访方面相似。两组在月经周期和生育能力的恢复方面也几乎相同。然而，孕三烯酮的副作用较少，且比达那唑更易于给药。我们得出结论，孕三烯酮是治疗患有子宫内膜异位症的不孕患者的一种有效药物。
