Thompson H J
AMC Cancer Research Center, Lakewood, Colorado 80214.
Cancer Res. 1993 May 15;53(10 Suppl):2442s-2445s.
Research in diet, nutrition, and cancer is multidisciplinary. As a result there are many factors to consider in the conceptualization and design of experiments that may not be readily apparent to someone entering this field. In this article issues are identified that should be considered in the development of hypotheses about the effects of diet and nutrition on the carcinogenic process and the evaluation of these hypotheses using animal models. The questions considered are: what comprises an acceptable rationale for diet, nutrition, and cancer experiments in which animal models are used; what factors should be considered in the design of these experiments; and what constitutes a mechanistic component in such animal studies.
饮食、营养与癌症方面的研究是多学科的。因此，在实验的概念化和设计中存在许多需要考虑的因素，而对于刚进入该领域的人来说，这些因素可能并不明显。本文确定了在提出关于饮食和营养对致癌过程影响的假设以及使用动物模型评估这些假设时应考虑的问题。所考虑的问题包括：在使用动物模型的饮食、营养与癌症实验中，什么构成了可接受的理论依据；在设计这些实验时应考虑哪些因素；以及在这类动物研究中，什么构成了机制性组成部分。
