Milatovich A, Mendel D B, Crabtree G R, Francke U
Department of Genetics, Stanford University, California 94305.
Genomics. 1993 Apr;16(1):292-5. doi: 10.1006/geno.1993.1182.
Hepatocyte nuclear factor-1 alpha (HNF-1 alpha; gene symbol, TCF1) forms dimers with itself as well as with HNF-1 beta and regulates the expression of several liver-specific genes. Recently, a dimerization cofactor of hepatocyte nuclear factor-1 alpha, called DCOH, has been identified. Here, we report the chromosomal localization of the genes for this cofactor to chromosomes 10 in both humans and mice by Southern blot analyses of somatic cell hybrids.
肝细胞核因子-1α（HNF-1α；基因符号，TCF1）可与自身以及HNF-1β形成二聚体，并调节多个肝脏特异性基因的表达。最近，已鉴定出一种名为DCOH的肝细胞核因子-1α二聚化辅因子。在此，我们通过对体细胞杂种进行Southern印迹分析，报告了该辅因子基因在人类和小鼠中均定位于10号染色体。
