人类血吸虫病的免疫学研究。II. 对曼氏血吸虫童虫具有细胞毒性的抗体。

Immunological studies in human schistosomiasis. II. Antibodies cytotoxic for Schistosoma mansoni schistosomules.

作者信息

Capron M, Camus D, Carlier Y, Figueiredo J F, Capron A

出版信息

Am J Trop Med Hyg. 1977 Mar;26(2):248-53. doi: 10.4269/ajtmh.1977.26.248.

DOI:10.4269/ajtmh.1977.26.248

Abstract

Complement dependent cytotoxic antibodies for Schistosoma mansoni schistosomules were studied in a Brazilian population. The sera of S. mansoni-infected patients gave a high percentage of cytotoxicity (63.4%) compared with sera from persons not infected (8.7%). The IgG class and the specificity of these cytotoxic antibodies are defined. The index of lethality appeared to be independent of the titers of other specific anti-S. mansoni antibodies. A statistical correlation was found between the index of lethality and both the severity of the disease and delayed hypersensitivity to S. mansoni antigen. The significance of cytotoxic antibodies in human schistosomiasis and their relevance to immunity in man are discussed.

摘要

在巴西人群中研究了针对曼氏血吸虫童虫的补体依赖性细胞毒性抗体。与未感染人群的血清（8.7%）相比，曼氏血吸虫感染患者的血清具有较高比例的细胞毒性（63.4%）。确定了这些细胞毒性抗体的IgG类别和特异性。致死指数似乎与其他特异性抗曼氏血吸虫抗体的滴度无关。发现致死指数与疾病严重程度和对曼氏血吸虫抗原的迟发型超敏反应之间存在统计学相关性。讨论了细胞毒性抗体在人类血吸虫病中的意义及其与人类免疫的相关性。

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