Roache J D, Cherek D R, Bennett R H, Schenkler J C, Cowan K A
Substance Abuse Research Center, University of Texas Mental Sciences Institute, Houston 77030.
J Clin Psychopharmacol. 1993 Feb;13(1):3-15.
Eight normal, healthy, male volunteers each received four triazolam doses (0, 2, 4, and 8 micrograms/kg) and four ethanol doses (0, 0.25, 0.5 and 1.0 g/kg) in a double-blind, double-dummy experiment in which within-subject dose sequence was determined by a balanced Latin square design. Triazolam and ethanol produced dose-related and time-related effects on subject ratings of mood and perceived drug effects and objective measures of memory and psychomotor performance. Dose-response curves for the two drugs were not parallel, and therefore, comparisons of the two drugs were based upon comparisons of the high dose of each drug. Although the two high-dose conditions generally were not different from one another, there were differences in their relative effect sizes, which were important. The high dose of each drug produced comparable degrees of impairment on two different psychomotor tasks. Triazolam, but not ethanol, produced significant impairment on two different memory tasks. The relative effects of each drug on subject ratings of mood and perceived drug effects varied across different subject-rated measures. Only ethanol significantly increased subject ratings of alcohol strength and feeling drunk. In comparison to ethanol, triazolam tended to produce less-pronounced subject ratings of drug effect magnitude, drug liking, and estimated performance impairment. However, less-pronounced subjective effects of triazolam were not universally observed on all subject ratings. Triazolam produced greater effects on several sedative symptoms and produced comparable effects on several mood factor scales.
在一项双盲、双模拟实验中，8名正常、健康的男性志愿者每人接受了4种三唑仑剂量（0、2、4和8微克/千克）和4种乙醇剂量（0、0.25、0.5和1.0克/千克），其中受试者内剂量顺序由平衡拉丁方设计确定。三唑仑和乙醇对受试者的情绪评分、感知到的药物效应以及记忆和精神运动表现的客观测量产生了剂量相关和时间相关的影响。两种药物的剂量反应曲线不平行，因此，两种药物的比较基于每种药物高剂量的比较。尽管两种高剂量条件通常彼此无差异，但它们的相对效应大小存在差异，这很重要。每种药物的高剂量对两项不同的精神运动任务产生了相当程度的损害。三唑仑而非乙醇对两项不同的记忆任务产生了显著损害。每种药物对受试者情绪评分和感知到的药物效应的相对影响在不同的受试者评分测量中有所不同。只有乙醇显著提高了受试者对酒精强度和醉酒感觉的评分。与乙醇相比，三唑仑往往使受试者对药物效应强度、药物喜好和估计的表现损害的评分不那么明显。然而，三唑仑不太明显的主观效应并非在所有受试者评分中都普遍观察到。三唑仑对几种镇静症状产生了更大的影响，对几种情绪因子量表产生了相当的影响。
