Berner M, Beghetti M, Ricou B, Rouge J C, Prêtre R, Friedli B
Unité de Soins Intensifs, Clinique de Pédiatrie, Genève, Switzerland.
Intensive Care Med. 1993;19(2):75-7. doi: 10.1007/BF01708365.
A 16-month-old girl developed severe pulmonary hypertension after closure of a large ventricular septal defect. All conventional therapeutic measures failed; an attempt to add nitric oxide at a continuous low dose to the inspired gas allowed resolution of pulmonary hypertension and low cardiac output. This report documents that continuous inhalation of low dose nitric oxide is capable of selective resolution of pulmonary hypertension following cardiac surgery for a large septal defect in a child. This suggests that a transient dysfunction in the release of nitric oxide by the pulmonary endothelial cell is responsible for the vasoconstriction.
一名16个月大的女孩在大型室间隔缺损闭合后出现严重肺动脉高压。所有传统治疗措施均告失败；尝试在吸入气体中持续添加低剂量一氧化氮后，肺动脉高压和低心输出量得以缓解。本报告证明，持续吸入低剂量一氧化氮能够选择性地缓解儿童大型间隔缺损心脏手术后的肺动脉高压。这表明肺内皮细胞释放一氧化氮的短暂功能障碍是血管收缩的原因。
