Fozo M S, Penney D G
Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201.
J Appl Toxicol. 1993 Mar-Apr;13(2):147-51. doi: 10.1002/jat.2550130213.
The goals of this study were to examine the cardiovascular and metabolic responses to a dihalogenated methane and to compare them to inhaled CO. One group of male Sprague-Dawley rats received an i.p. injection of either 3 or 6 mmol kg-1 dibromomethane (DBM) diluted 1:3 with sesame oil. Measurements of carboxyhemoglobin (COHb), rectal body temperature (BT), heart rate, systolic blood pressure (BP) and blood glucose and lactate concentrations were made at times 0, 30, 60, 120, 240, 360, 480, 600, 720, 840, 1020, 1440 and 1680 min. A second group of rats received only sesame oil and was tested in the same manner. A third group of rats breathed 225 ppm CO for 120 min before being tested. Peak COHb levels were 16% 8 h after 3 mmol kg-1 DBM, 18% 12 h after 6 mmol kg-1 DBM and 17% in the CO-exposed group. The sesame oil controls exhibited no elevation in COHb. The BT dropped by ca. 1 degree C in both the DBM- and CO-exposed rats, while there was no BT change in the sesame oil controls. The BT dropped by 1.0 degree C and 1.2 degree C after 6 h in the 3 and 6 mmol kg-1 DBM groups, respectively, and by 0.9 degree C after 120 min in the CO-exposed group. The CO-exposed rats displayed a 12 mmHg decrease in systolic BP, while both doses of DBM failed to produce any significant BP change. The BP in the sesame oil controls remained constant.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是检测二卤代甲烷对心血管和代谢的反应，并将其与吸入一氧化碳的反应进行比较。一组雄性Sprague-Dawley大鼠腹腔注射用芝麻油按1:3稀释的3或6 mmol kg-1二溴甲烷（DBM）。在0、30、60、120、240、360、480、600、720、840、1020、1440和1680分钟时测量碳氧血红蛋白（COHb）、直肠体温（BT）、心率、收缩压（BP）以及血糖和乳酸浓度。第二组大鼠仅注射芝麻油，并以相同方式进行测试。第三组大鼠在测试前吸入225 ppm一氧化碳120分钟。3 mmol kg-1 DBM组在8小时后COHb峰值水平为16%，6 mmol kg-1 DBM组在12小时后为18%，一氧化碳暴露组为17%。芝麻油对照组的COHb无升高。DBM暴露组和一氧化碳暴露组的BT均下降约1摄氏度，而芝麻油对照组的BT无变化。3和6 mmol kg-1 DBM组在6小时后BT分别下降1.0摄氏度和1.2摄氏度，一氧化碳暴露组在120分钟后下降0.9摄氏度。一氧化碳暴露组的大鼠收缩压下降12 mmHg，而两种剂量的DBM均未产生任何显著的血压变化。芝麻油对照组的血压保持恒定。（摘要截断于250字）
