Lammie P J, Addiss D G, Leonard G, Hightower A W, Eberhard M L
Parasitic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30341.
J Infect Dis. 1993 May;167(5):1178-83. doi: 10.1093/infdis/167.5.1178.
The relationship between chronic obstructive disease and antifilarial immune responsiveness was studied in the Haitian community of Leogane, where Wuchereria bancrofti is endemic. Differences in sex ratios and in the prevalence of microfilaremia were observed between patients with hydrocele and those with lymphedema or elephantiasis of the lower limb. Only 2 of 84 patients with limb involvement (74 women, 10 men) were microfilaremic compared with 25 of 42 men with hydrocele. Microfilaria-positive men with hydrocele had significantly lower IgG2 and proliferative responses to filarial antigen than did amicrofilaremic men with hydrocele or individuals with lymphedema or elephantiasis. Parasite-specific cellular responses of amicrofilaremic individuals with obstructive disease were greater, although not significantly so, than those of amicrofilaremic asymptomatic members of the community. These results are compatible with the hypothesis that development of obstructive disease of the lymphatics has an immune component in amicrofilaremic persons.
在班氏吴策线虫为地方病的海地莱奥甘社区，研究了慢性阻塞性疾病与抗丝虫免疫反应性之间的关系。观察到患有鞘膜积液的患者与患有下肢淋巴水肿或象皮肿的患者在性别比例和微丝蚴血症患病率方面存在差异。在84例肢体受累患者（74名女性，10名男性）中，只有2例有微丝蚴血症，而42例患有鞘膜积液的男性中有25例有微丝蚴血症。患有鞘膜积液且微丝蚴阳性的男性对丝虫抗原的IgG2和增殖反应明显低于患有鞘膜积液但无微丝蚴血症的男性或患有淋巴水肿或象皮肿的个体。患有阻塞性疾病且无微丝蚴血症个体的寄生虫特异性细胞反应比社区中无症状且无微丝蚴血症的成员略高，尽管差异不显著。这些结果与以下假设相符：在无微丝蚴血症的个体中，淋巴管阻塞性疾病的发生具有免疫成分。
