Barrios N J
Tulane University School of Medicine, New Orleans.
J La State Med Soc. 1993 Apr;145(4):151-5.
A retrospective analysis identified 40 children and adolescents with nasopharyngeal carcinoma who were evaluated and treated at the Medical Center of Louisiana from 1948 through 1992. The male to female ratio was 1.8:1. Thirty-two patients had lymphoepithelioma and 8 had squamous cell carcinoma. Twenty-three children had primary lesions confined to the nasopharynx. In 8 patients, the tumor extended into the nasal cavity or oropharynx, and 7 patients had tumor invasion of skull or cranial nerve. Thirty-one had palpable cervical lymphadenopathy. There were no documented distant metastasis at presentation. All patients were treated with primary radiotherapy, and 9 patients also had chemotherapy containing cisplatin, fluorouracil, bleomycin, cyclophosphamide, and doxorubicin. Ten are alive 5 to 30 years from time of diagnosis (median 10 years). Distant metastasis was the initial cause of failure. Though not a controlled study, bias in the data insinuate an improved prognosis for male patients, age > 10 years, tumor limited to the nasopharynx without extension (T1-2), absence or single positive homolateral node (N0-1), and patients who received chemotherapy.
一项回顾性分析确定了1948年至1992年期间在路易斯安那州医疗中心接受评估和治疗的40例儿童和青少年鼻咽癌患者。男女比例为1.8:1。32例患者患有淋巴上皮瘤，8例患有鳞状细胞癌。23名儿童的原发性病变局限于鼻咽部。8例患者的肿瘤扩展至鼻腔或口咽，7例患者的肿瘤侵犯颅骨或颅神经。31例有可触及的颈部淋巴结病。就诊时均无远处转移记录。所有患者均接受了原发性放射治疗，9例患者还接受了含有顺铂、氟尿嘧啶、博来霉素、环磷酰胺和阿霉素的化疗。从诊断时起，10例患者存活5至30年（中位10年）。远处转移是最初的失败原因。尽管这不是一项对照研究，但数据中的偏差表明男性患者、年龄>10岁、肿瘤局限于鼻咽部无扩展（T1-2）、无或单个同侧阳性淋巴结（N0-1）以及接受化疗的患者预后有所改善。
