Solomon N P, Hixon T J
Department of Speech Pathology and Audiology, University of Iowa, Iowa City 52242.
J Speech Hear Res. 1993 Apr;36(2):294-310. doi: 10.1044/jshr.3602.294.
Breathing was investigated in 14 male subjects with Parkinson's disease and 14 healthy male control subjects. Kinematic, spirometric, acoustic, and pressure data were used to assess function during resting tidal breathing, reading aloud, and monologue production. Data were collected at two times during the drug cycle for subjects with Parkinson's disease. During resting tidal breathing, subjects with Parkinson's disease, on average, had a faster breathing rate, greater minute ventilation, and smaller relative contribution of the rib cage to lung volume change than did healthy control subjects. During speech breathing, rib cage volume was smaller and abdominal volume was larger at initiation of the breath groups for subjects with Parkinson's disease than for healthy control subjects. Subjects with Parkinson's disease produced fewer words and spent less time producing speech per breath group and tended to have a faster interpause speech rate than did healthy control subjects. There was no difference between groups for duration of inspirations between speech breath groups. Oral pressure was lower for subjects with Parkinson's disease but estimated tracheal pressure did not differ between the two subject groups. Few differences were found between the two times in the drug cycle for resting and speech breathing. Results provide indirect evidence for reduced relative compliance of the rib cage to the abdomen for subjects with Parkinson's disease as compared to healthy control subjects. In addition, the results support the possibility of inadequate valving of the air stream for subjects with Parkinson's disease.
对14名帕金森病男性患者和14名健康男性对照者的呼吸情况进行了研究。运动学、肺量计、声学和压力数据用于评估静息潮气呼吸、大声朗读和独白时的功能。在帕金森病患者的药物周期中，在两个时间点收集数据。在静息潮气呼吸时，帕金森病患者平均呼吸频率更快，分钟通气量更大，胸廓对肺容积变化的相对贡献比健康对照者小。在言语呼吸时，帕金森病患者呼吸组开始时胸廓容积比健康对照者小，腹部容积比健康对照者大。帕金森病患者每个呼吸组说出的单词较少，用于言语表达的时间较少，且言语间歇率往往比健康对照者快。两组之间言语呼吸组吸气持续时间没有差异。帕金森病患者的口腔压力较低，但两组之间估计的气管压力没有差异。在药物周期的两个时间点，静息和言语呼吸方面几乎没有发现差异。结果提供了间接证据，表明与健康对照者相比，帕金森病患者胸廓相对于腹部的相对顺应性降低。此外，结果支持帕金森病患者气流瓣膜功能不足的可能性。
