De Ritis L, Pecorari R, Contiero M R
Divisione di Pediatria, Ospedale F.lli Borselli, Bondeno (FE), Italia.
Pediatr Med Chir. 1993 Jan-Feb;15(1):53-5.
Cholestatic jaundice is a well-known complication of gram-negative bacterial infections in the neonates. Newborn and premature infants are particularly vulnerable to cholestasis because of immaturities in bile forming mechanisms. The Authors describe two premature infants who developed cholestasis in the course of a proved bacterial infection by Klebsiella pneumoniae. The main clinical aspects of this association are illustrated and the recent concepts of pathogenetic mechanism of intrahepatic cholestasis is discussed.
胆汁淤积性黄疸是新生儿革兰氏阴性菌感染的一种常见并发症。由于胆汁形成机制不成熟，新生儿和早产儿尤其易患胆汁淤积。作者描述了两名早产儿，他们在确诊为肺炎克雷伯菌感染的过程中出现了胆汁淤积。本文阐述了这种关联的主要临床特征，并讨论了肝内胆汁淤积发病机制的最新概念。
