[小鼠高反应和低反应品系（HL和LL）及其杂种中IgE和血凝抗体合成的遗传分析]
[Genetic analysis of the synthesis of IgE and hemagglutinating antibodies in high and low responder lines (HL and LL) of mice and their hybrids].
作者信息
Prouvost-Danon A, Mouton D, Abadie A, Mevel J C, Biozzi G
出版信息
Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):307-9.
PMID:848891
Abstract
Immune responses depend upon the dose of antigen and the line of mice. Threshold doses of antigen are lower in HL, higher in LL and intermediate in hybrids. The responses obtained in F1, F2 and backcrosses demonstrate the genetic control of the interline difference. The correlation between IgE and hemagglutinating antibodies responses suggests a common genetic control for the synthesis of the two types of antibodies.
摘要
免疫反应取决于抗原剂量和小鼠品系。高反应品系（HL）的抗原阈值剂量较低，低反应品系（LL）的较高，而杂交品系的则处于中间水平。在F1、F2和回交中获得的反应证明了品系间差异的遗传控制。IgE与血凝抗体反应之间的相关性表明这两种抗体的合成存在共同的遗传控制。
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