Fournié G J, Lambert P H, Miescher P A
Clin Exp Immunol. 1976 Oct;26(1):46-51.
The genetic control of the immune response to DNA was studied in various strains of mice F1 hybrids and corresponding back-crosses immunized with single stranded DNA complexed to methylated bovine serum albumin. Anti-DNA antibody response was measured by radioimmuno-logical technique. High responder, low responder, and intermediate responder strains were found and the ability to respond to DNA was characterized as a dominant genetic trait which is not linked to the major locus of histocompatibility. Studies in back-crosses suggested that this immune response is under multigenic control. High responder mice produce both anti-double stranded DNA and anti-single stranded DNA 7S and 19S antibodies, while low responder mice produce mainly anti-single stranded DNA 19S antibodies.
研究了用与甲基化牛血清白蛋白复合的单链DNA免疫的不同品系小鼠、F1杂种及相应回交后代对DNA免疫反应的遗传控制。通过放射免疫技术测定抗DNA抗体反应。发现了高反应品系、低反应品系和中间反应品系，对DNA的反应能力被表征为一种显性遗传性状，它与主要组织相容性位点无关。回交研究表明这种免疫反应受多基因控制。高反应小鼠产生抗双链DNA和抗单链DNA的7S和19S抗体，而低反应小鼠主要产生抗单链DNA的19S抗体。
