Devor E J, Cloninger C R, Kwan S W, Abell C W
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242-1057.
Alcohol Clin Exp Res. 1993 Apr;17(2):263-7. doi: 10.1111/j.1530-0277.1993.tb00760.x.
Platelet monoamine oxidase B (MAO B) activity and concentration were studied in a small sample of alcoholic families (n = 8) and in 20 unrelated, nonalcoholic controls. Complex segregation analyses of familial data indicated that both activity and concentration are controlled by a single major gene locus with a multifactorial background effect accounting for 0-50% of the variance. When the alcoholic family members (n = 24) were compared with the controls, all determinations of activity display significant differences, whereas MAO B concentration levels showed no difference. These results indicated that the lowered MAO B activities frequently reported among alcoholics do not reflect a change in the number of MAO B macromolecules expressed in platelets, but could be caused by the presence of an inhibitor or by a polymorphic or variant form of the enzyme.
在一小群酗酒家族样本（n = 8）和20名无亲缘关系的非酗酒对照者中，研究了血小板单胺氧化酶B（MAO B）的活性和浓度。对家族数据的复杂分离分析表明，活性和浓度均由一个主要基因位点控制，多因素背景效应占变异的0 - 50%。当将酗酒家族成员（n = 24）与对照者进行比较时，所有活性测定均显示出显著差异，而MAO B浓度水平则无差异。这些结果表明，酗酒者中经常报道的MAO B活性降低并不反映血小板中表达的MAO B大分子数量的变化，而是可能由抑制剂的存在或该酶的多态性或变异形式引起。
