嘌呤和嘧啶对曲霉属真菌中5-氟胞嘧啶抑菌活性的影响。
Effects of purines and pyrimidines on the fungistatic activity of 5-fluorocytosine in Aspergillus species.
作者信息
Wagner G E, Shadomy S
出版信息
Antimicrob Agents Chemother. 1977 Feb;11(2):229-33. doi: 10.1128/AAC.11.2.229.
Abstract
The ability of some exogenously supplied purines, pyrimidines, and their nucleosides to antagonize the in vitro fungistatic activity of 5-fluorocytosine (5-FC) in Aspergillus species was examined. All compounds tested except thymidine were capable of altering the minimal inhibitory concentration of 5-FC for seven strains of aspergilli tested. In most instances, there was a reciprocal correlation between the ability of a compound to antagonize the fungistatic activity of 5-FC and the quantity of 5-FC taken up by cells in the presence of the compound over a 72-h period.
摘要
研究了一些外源性提供的嘌呤、嘧啶及其核苷拮抗5-氟胞嘧啶（5-FC）对曲霉属真菌体外抑菌活性的能力。除胸苷外，所有测试化合物均能改变5-FC对7株受试曲霉的最低抑菌浓度。在大多数情况下，一种化合物拮抗5-FC抑菌活性的能力与该化合物存在时细胞在72小时内摄取的5-FC量之间呈负相关。
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Effects of purines and pyrimidines on the fungistatic activity of 5-fluorocytosine in Aspergillus species.嘌呤和嘧啶对曲霉属真菌中5-氟胞嘧啶抑菌活性的影响。
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Fungistatic activity, uptake and incorporation of 5-fluorocytosine in Candida albicans, as influenced by pyrimidines and purines. I. Reversal experiments.嘧啶和嘌呤对白色念珠菌中5-氟胞嘧啶的抑菌活性、摄取及掺入的影响。I. 反向实验
Pathol Microbiol (Basel). 1973;39(2):148-59. doi: 10.1159/000162642.
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