Chiba S, Fujimaki E, Nakano O, Orii S, Sato S, Sasaki K
First Dept. of Internal Medicine, Iwate Medical University, School of Medicine.
Gan To Kagaku Ryoho. 1993 Apr;20(6):767-70.
Flow cytometric measurement of nuclear DNA content in 159 colorectal adenomas was carried out to investigate the relationship between DNA ploidy and the histological findings. DNA aneuploidy was detected in 18 lesions (12.8%). The incidence of DNA aneuploidy was significantly higher in tubulovillous adenomas than in tubular adenomas (30.4% vs. 8.1%; p < 0.01). DNA aneuploidy was not found in any adenoma with mild dysplasia, but was noted in 19.1% of those with moderate dysplasia and in 33.3% of those with severe dysplasia. The mean size of the lesions was significantly larger in adenomas with aneuploidy than in those without aneuploidy (14.0 mm vs. 7.7 mm; p < 0.01). The DNA index values of 18 adenomas with aneuploidy were divided into two groups: one ranged from 1.07 to 1.23 and the other from 1.66 to 1.85. DNA index values correlated with the size of the lesions (p < 0.05), but not with the histologic type and degree of dysplasia.
对159例大肠腺瘤进行流式细胞术检测核DNA含量，以研究DNA倍体与组织学表现之间的关系。在18个病变（12.8%）中检测到DNA非整倍体。绒毛管状腺瘤中DNA非整倍体的发生率显著高于管状腺瘤（30.4%对8.1%；p<0.01）。轻度不典型增生的腺瘤中未发现DNA非整倍体，但中度不典型增生的腺瘤中有19.1%发现DNA非整倍体，重度不典型增生的腺瘤中有33.3%发现DNA非整倍体。非整倍体腺瘤的病变平均大小显著大于无非整倍体的腺瘤（14.0mm对7.7mm；p<0.01）。18个非整倍体腺瘤的DNA指数值分为两组：一组为1.07至1.23，另一组为1.66至1.85。DNA指数值与病变大小相关（p<0.05），但与组织学类型和不典型增生程度无关。
