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肌萎缩侧索硬化症中的脊髓液细胞与蛋白质

Spinal fluid cells and protein in amyotrophic lateral sclerosis.

作者信息

Norris F H, Burns W, U K S, Mukai E, Norris H

机构信息

Amyotrophic Lateral Sclerosis Research Foundation, California Pacific Medical Center, San Francisco.

出版信息

Arch Neurol. 1993 May;50(5):489-91. doi: 10.1001/archneur.1993.00540050041012.

DOI:10.1001/archneur.1993.00540050041012
PMID:8489404
Abstract

The cerebrospinal fluid total protein in 385 cases of sporadic amyotrophic lateral sclerosis showed no relationship to survival, but it was related to survival time in 34 cases of familial amyotrophic lateral sclerosis. Infrequent and mild pleocytosis, and oligoclonal bands seemed to have no clinical significance in well established cases of amyotrophic lateral sclerosis.

摘要

385例散发性肌萎缩侧索硬化患者的脑脊液总蛋白与生存率无关,但在34例家族性肌萎缩侧索硬化患者中,脑脊液总蛋白与生存时间有关。在确诊的肌萎缩侧索硬化病例中,偶发且轻微的细胞数增多和寡克隆带似乎无临床意义。

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Spinal fluid cells and protein in amyotrophic lateral sclerosis.肌萎缩侧索硬化症中的脊髓液细胞与蛋白质
Arch Neurol. 1993 May;50(5):489-91. doi: 10.1001/archneur.1993.00540050041012.
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[Amyotrophic lateral sclerosis and neurosyphilis].[肌萎缩侧索硬化症与神经梅毒]
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Transglutaminase activity in serum and cerebrospinal fluid in sporadic amyotrophic lateral sclerosis: a possible use as an indicator of extent of the motor neuron loss.散发性肌萎缩侧索硬化症患者血清和脑脊液中的转谷氨酰胺酶活性:作为运动神经元丢失程度指标的一种可能用途。
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Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia.肌萎缩侧索硬化症患者脑脊液中的病因因子主要诱导小胶质细胞产生促炎反应。
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[Cerebrospinal fluid proteins in the course of amyotrophic lateral sclerosis].
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Is cerebrospinal fluid obtained for diagnostic purpose a good material for biomarker studies in amyotrophic lateral sclerosis?用于诊断目的获取的脑脊液是肌萎缩侧索硬化症生物标志物研究的良好材料吗?
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引用本文的文献

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Does Lumbar Puncture Still Have Clinical Value for Patients with Amyotrophic Lateral Sclerosis?腰椎穿刺对肌萎缩侧索硬化症患者仍具有临床价值吗?
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Associations of cerebrospinal fluid profiles with severity and mortality risk of amyotrophic lateral sclerosis.脑脊液特征与肌萎缩侧索硬化症严重程度及死亡风险的关联。
Front Neurosci. 2024 May 15;18:1375892. doi: 10.3389/fnins.2024.1375892. eCollection 2024.
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Elevated Cerebrospinal Fluid Proteins and Albumin Determine a Poor Prognosis for Spinal Amyotrophic Lateral Sclerosis.
脑脊液蛋白和白蛋白升高预示着脊髓肌萎缩预后不良。
Int J Mol Sci. 2022 Sep 21;23(19):11063. doi: 10.3390/ijms231911063.
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Concomitant amyotrophic lateral sclerosis and paraclinical laboratory features of multiple sclerosis: coincidence or causal relationship?肌萎缩侧索硬化症与多发性硬化症的伴发及副临床实验室特征:巧合还是因果关系?
BMJ Case Rep. 2013 Jan 23;2013:bcr2012007975. doi: 10.1136/bcr-2012-007975.