Tsukada K, Katoh H, Shiojima M, Takenoshita S, Nagamachi Y
Department of Surgery I, Gunma University, School of Medicine, Maebashi, Japan.
APMIS. 1993 Feb;101(2):97-100.
In order to study the mortality rate and bacteremia, plasma endotoxin, and plasma endothelin-1 levels in antibiotic therapy for E. coli peritonitis, blood samples were obtained from rats given intraperitoneal injections of latamoxef or placebo. Intraperitoneal injections of latamoxef improved the prognosis of peritonitis rats. Two h after treatment, bacteremia levels were noticeably higher in rats treated with placebo than in rats treated with latamoxef, but the latamoxef-treated group manifested a significant elevation of plasma endotoxin and endothelin-1 levels compared to the placebo-treated group. The results of this study demonstrate that treating E. coli septic peritonitis with selected antibiotics induces increased plasma endotoxin levels, which are associated with elevation of plasma endothelin-1 levels.
为了研究大肠杆菌性腹膜炎抗生素治疗中的死亡率、菌血症、血浆内毒素及血浆内皮素 -1 水平，从腹腔注射拉氧头孢或安慰剂的大鼠获取血样。腹腔注射拉氧头孢改善了腹膜炎大鼠的预后。治疗后两小时，安慰剂治疗组大鼠的菌血症水平明显高于拉氧头孢治疗组，但与安慰剂治疗组相比，拉氧头孢治疗组的血浆内毒素和内皮素 -1 水平显著升高。本研究结果表明，用所选抗生素治疗大肠杆菌性败血症性腹膜炎会导致血浆内毒素水平升高，这与血浆内皮素 -1 水平升高有关。
