Tsukada K, Katoh H, Shiojima M, Suzuki T, Takenoshita S, Nagamachi Y
First Department of Surgery, Gunma University, School of Medicine, Maebashi, Japan.
Exp Clin Endocrinol. 1993;101(5):315-8. doi: 10.1055/s-0029-1211251.
To study the diabetic mellitus (DM) patient's reaction to sepsis, we investigated the survival rate, the bacteremia, plasma endotoxin and plasma endothelin-1 levels in E. coli septic peritonitis rats with or without streptozotocin-induced DM. No significant difference could be detected between the DM and nondiabetic rats in the survival rate, the bacteremia level or the plasma endotoxin level. The DM rat manifested a significant increase compared to the nondiabetic rat in the plasma endothelin-1 level four hours after the outbreak of peritonitis. Endothelin-1 may thus play some role in the E. coli septic peritonitis rat with DM.
为研究糖尿病（DM）患者对败血症的反应，我们调查了链脲佐菌素诱导的糖尿病大鼠和非糖尿病大鼠在大肠杆菌性脓毒症性腹膜炎中的存活率、菌血症、血浆内毒素和血浆内皮素-1水平。糖尿病大鼠和非糖尿病大鼠在存活率、菌血症水平或血浆内毒素水平上未检测到显著差异。与非糖尿病大鼠相比，糖尿病大鼠在腹膜炎发作4小时后血浆内皮素-1水平显著升高。因此，内皮素-1可能在患有糖尿病的大肠杆菌性脓毒症性腹膜炎大鼠中起一定作用。
