Pirttilä T, Järvenpää R, Dastidar P, Frey H
Department of Neurology, University Hospital, Tampere, Finland.
Acta Radiol. 1993 May;34(3):296-302.
A quantitative and qualitative analysis was done of 187 CT examinations in 59 healthy subjects and 128 patients with various neurodegenerative diseases. The rates of agreement between quantitative measurements and the qualitative grading by two observers were 76.7% for the evaluation of lateral ventricular size and 66.3% for the assessment of sulcal size. Increase in the width of the 3rd ventricle, in the bi-caudate span, and in the area of the lateral ventricles reflected a pathologic enlargement of the ventricles. The profile of ventricular dilatation in dementia patients was different from that of other patients with brain atrophy. However, the quantitative measurement of brain atrophy by a computer-based method did not increase the differential diagnostic accuracy among dementia patients. The results stress the importance of the selection of valid measures in the evaluation of structural changes of the brain. We suggest the use of reference scans for improving the reliability of the visual evaluation.
对59名健康受试者和128名患有各种神经退行性疾病的患者进行了187次CT检查的定量和定性分析。两名观察者对侧脑室大小的定量测量与定性分级之间的一致性率为76.7%，脑沟大小评估的一致性率为66.3%。第三脑室宽度、双侧尾状核间距和侧脑室面积的增加反映了脑室的病理性扩大。痴呆患者脑室扩张的特征与其他脑萎缩患者不同。然而，通过基于计算机的方法对脑萎缩进行定量测量并没有提高痴呆患者之间的鉴别诊断准确性。结果强调了在评估脑结构变化时选择有效测量方法的重要性。我们建议使用参考扫描来提高视觉评估的可靠性。
