Zurita M, Vaquero J, Coca S, Oya S, Garcia N
Laboratory of Experimental Neuro-oncology, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Histol Histopathol. 1993 Apr;8(2):345-50.
The presence of IOT-10-positive lymphocytes among the tumor-infiltrating-lymphocyte (TIL) population was studied in a series of 185 brain tumors. In most of the tumors, IOT-10-positive lymphocytes were identified, but generally they were scarce and masked among the tumor cells, suggesting that NK-cells exercise a poor participation in the tissular response against brain tumors. Isolated tumor cells showing IOT-10-positivity were found in low-grade astrocytomas, neurinomas and medulloblastomas. IOT-10-positivity on both tumor neuropil and tumor cells was considered a characteristic finding in oligodendrogliomas. The number of IOT-10-positive NK-cells in brain metastases and in cerebellar hemangioblastomas was comparatively greater than in other types of brain tumor. Since in brain metastases, the presence of IOT-10-positive NK-cells can be related to the tissular response to an extracerebral malignancy, their considerable presence in cerebellar hemangioblastomas is an enigmatic finding that deserves further attention.
在一系列185例脑肿瘤中，研究了肿瘤浸润淋巴细胞（TIL）群体中IOT - 10阳性淋巴细胞的存在情况。在大多数肿瘤中，可识别出IOT - 10阳性淋巴细胞，但通常它们数量稀少且隐匿于肿瘤细胞之中，这表明自然杀伤细胞（NK细胞）在针对脑肿瘤的组织反应中参与度较低。在低级别星形细胞瘤、神经鞘瘤和髓母细胞瘤中发现了呈IOT - 10阳性的孤立肿瘤细胞。肿瘤神经毡和肿瘤细胞上的IOT - 10阳性被认为是少突胶质细胞瘤的特征性表现。脑转移瘤和小脑血管母细胞瘤中IOT - 10阳性NK细胞的数量相对多于其他类型的脑肿瘤。由于在脑转移瘤中，IOT - 10阳性NK细胞的存在可能与对脑外恶性肿瘤的组织反应有关，它们在小脑血管母细胞瘤中的大量存在是一个值得进一步关注的神秘发现。
