Merin G, Bitran D, Uretzky G, Superstine E, Cotev S, Borman J B
Ann Thorac Surg. 1977 Apr;23(4):361-3. doi: 10.1016/s0003-4975(10)64142-2.
The hemodynamic effects of dopamine were studied in 19 patients following intracardiac operation or myocardial revascularization using extracorporeal circulation. The heart rate, mean blood pressure, central venous pressure, left atrial and pulmonary artery pressures, cardiac output, and urine output were recorded before and at the end of one-hour infusions of dopamine at 5, 10, and 15 mug/kg/min. Infusion of 5 mug/kg/min of dopamine resulted in the highest gain in cardiac output and stroke work without an increase in myocardial oxygen consumption, as evidenced by lack of significant rise in heart rate. In addition, this dosage was not accompanied by an increase in pulmonary or systemic vascular resistance, nor were other untoward effects observed after administration of 5 mug/kg/min of dopamine.
在19例接受心内手术或采用体外循环进行心肌血运重建的患者中，研究了多巴胺的血流动力学效应。在以5、10和15微克/千克/分钟的速度输注多巴胺1小时之前和结束时，记录心率、平均血压、中心静脉压、左心房和肺动脉压力、心输出量和尿量。输注5微克/千克/分钟的多巴胺导致心输出量和每搏功增加最多，且心肌氧耗量未增加，心率无显著升高即证明了这一点。此外，该剂量并未伴有肺血管或体循环血管阻力增加，在输注5微克/千克/分钟的多巴胺后也未观察到其他不良反应。
