Dion I, Roques X, Baquey C, Baudet E, Basse Cathalinat B, More N
INSERM U.306, Université Bordeaux II 146, France.
Biomed Mater Eng. 1993 Spring;3(1):51-5.
The new prosthetic heart valve that has been designed by FII Company and Pr. Baudet involves a new "composite" material: titanium alloy T16A14V coated with Diamond-like Carbon. The purpose of this study was to evaluate the in vitro hemocompatibility of this new material in terms of protein adsorption and platelet retention. The static protein adsorption test gave interesting results, particularly for the albumin assay (237%) compared to the results obtained with a silicone elastomer chosen as a reference; the fibrinogen quantity, adsorbed on the surface of the material was slightly higher than that adsorbed on the silicone surface. Platelets adhere quite twice as much as they do on the reference surface. Such investigations showed good hemocompatibility results and should initiate further studies.
由FII公司和鲍德教授设计的新型人工心脏瓣膜采用了一种新型“复合材料”：涂有类金刚石碳的钛合金T16A14V。本研究的目的是从蛋白质吸附和血小板滞留方面评估这种新材料的体外血液相容性。静态蛋白质吸附试验给出了有趣的结果，特别是白蛋白测定（237%），与选用的作为参考的硅橡胶弹性体所获结果相比；吸附在材料表面的纤维蛋白原量略高于吸附在硅橡胶表面的量。血小板的黏附量是参考表面上的两倍左右。此类研究显示出良好的血液相容性结果，应启动进一步研究。
