Interaction of quinidine and propranolol in experimental cardiac arrhythmias in the dog.
作者信息
Madan B R, Pendse V K
出版信息
Arch Int Pharmacodyn Ther. 1977 Feb;225(2):287-93.
PMID:849075
Abstract
Quinidine, propranolol and their combination were studied in atrial fibrillation induced by the topical application of acetylcholine or aconitine, injury-stimulation-induced atrial flutter and ventricular ectopic tachycardia produced by coronary occlusion in the dog. The effect of combination of quinidine and propranolol was significantly greater than that of the individual drug in atrial arrhythmias but not in ventricular arrhythmias. The study provides experimental support for the combined clinical use of quinidine and propranolol in the treatment of atrial arrhythmias.
摘要
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