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肾细胞癌的免疫疗法。

Immunotherapy of renal cell carcinoma.

作者信息

Haas G P, Hillman G G, Redman B G, Pontes J E

机构信息

Department of Urology, Wayne State University School of Medicine, Detroit, Michigan.

出版信息

CA Cancer J Clin. 1993 May-Jun;43(3):177-87. doi: 10.3322/canjclin.43.3.177.

DOI:10.3322/canjclin.43.3.177
PMID:8490757
Abstract

Immunologic approaches to the therapy of metastatic renal cell carcinoma have provided moderate improvement in response rates for a disease that is extremely resistant to all forms of treatment. This article reviews recent clinical efforts using immunotherapy for renal cell carcinoma, including the adoptive transfer of cytotoxic killer cells and/or the use of biologic response modifiers, such as interferon and interleukin-2.

摘要

对于对所有形式治疗都极具抗性的转移性肾细胞癌,免疫治疗方法已使缓解率有了一定程度的提高。本文综述了近期使用免疫疗法治疗肾细胞癌的临床研究,包括细胞毒性杀伤细胞的过继性转移和/或使用生物反应调节剂,如干扰素和白细胞介素-2。

相似文献

1
Immunotherapy of renal cell carcinoma.肾细胞癌的免疫疗法。
CA Cancer J Clin. 1993 May-Jun;43(3):177-87. doi: 10.3322/canjclin.43.3.177.
2
Combination biologic therapy with interleukin-2 and interferon-alfa in the outpatient treatment of metastatic renal cell carcinoma.白细胞介素-2与α干扰素联合生物疗法用于转移性肾细胞癌的门诊治疗
Semin Oncol. 1993 Dec;20(6 Suppl 9):11-5.
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Cancer immunotherapy using tumor-infiltrating lymphocytes.使用肿瘤浸润淋巴细胞的癌症免疫疗法。
Semin Hematol. 1992 Apr;29(2 Suppl 1):33-5.
4
Adoptive immunotherapy with tumor-infiltrating lymphocytes and interleukin-2 in patients with metastatic malignant melanoma and renal cell carcinoma: a pilot study.转移性恶性黑色素瘤和肾细胞癌患者采用肿瘤浸润淋巴细胞和白细胞介素-2进行过继性免疫治疗:一项试点研究。
J Clin Oncol. 1995 Aug;13(8):1939-49. doi: 10.1200/JCO.1995.13.8.1939.
5
Interferon-alpha primed tumor-infiltrating lymphocytes combined with interleukin-2 and interferon-alpha as therapy for metastatic renal cell carcinoma.α干扰素预处理的肿瘤浸润淋巴细胞联合白细胞介素-2和α干扰素治疗转移性肾细胞癌。
J Urol. 1993 Nov;150(5 Pt 1):1384-90. doi: 10.1016/s0022-5347(17)35785-3.
6
Patterns of relapse and response to retreatment in patients with metastatic melanoma or renal cell carcinoma who responded to interleukin-2-based immunotherapy.接受基于白细胞介素-2免疫疗法治疗后出现反应的转移性黑色素瘤或肾细胞癌患者的复发模式及对再治疗的反应
Cancer J Sci Am. 1998 Mar-Apr;4(2):86-93.
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Immunologic approaches to the treatment of cancer.癌症治疗的免疫学方法。
Cancer Invest. 1995;13(3):339-40. doi: 10.3109/07357909509094469.
8
Adoptive cellular therapy.过继性细胞疗法
Semin Oncol. 2000 Apr;27(2):221-33.
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Adoptive immunotherapy of renal cell carcinoma: studies from the Surgery Branch, National Cancer Institute.肾细胞癌的过继性免疫治疗:美国国立癌症研究所外科分部的研究
Semin Urol. 1993 Feb;11(1):41-3.
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Cellular therapy: scientific rationale and clinical results in the treatment of metastatic renal-cell carcinoma.细胞疗法:转移性肾细胞癌治疗的科学原理与临床结果
Semin Oncol. 1995 Feb;22(1):74-80.

引用本文的文献

1
Treatment of metastatic renal cell carcinoma.转移性肾细胞癌的治疗。
Nat Rev Urol. 2010 Jun;7(6):327-38. doi: 10.1038/nrurol.2010.57. Epub 2010 May 11.
2
Two randomised phase II trials of subcutaneous interleukin-2 and histamine dihydrochloride in patients with metastatic renal cell carcinoma.两项关于皮下注射白细胞介素-2和二盐酸组胺治疗转移性肾细胞癌患者的随机II期试验。
Br J Cancer. 2005 Oct 3;93(7):757-62. doi: 10.1038/sj.bjc.6602768.
3
In vivo assessment of the antiproliferative properties of interferon-alpha during immunotherapy: Ki-67 (MIB-1) in patients with metastatic renal cell carcinoma.
免疫治疗期间干扰素-α抗增殖特性的体内评估:转移性肾细胞癌患者中的Ki-67(MIB-1)
Br J Cancer. 2004 Feb 9;90(3):626-31. doi: 10.1038/sj.bjc.6601587.
4
L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases.L型和M2型丙酮酸激酶在肾细胞癌及其转移灶中的表达
Virchows Arch. 1994;424(2):177-85. doi: 10.1007/BF00193498.
5
Growth and major histocompatibility antigen expression regulation by IL-4, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) on human renal cell carcinoma.白细胞介素-4、γ干扰素(IFN-γ)和肿瘤坏死因子-α(TNF-α)对人肾细胞癌生长及主要组织相容性抗原表达的调控
Clin Exp Immunol. 1994 Jun;96(3):476-83. doi: 10.1111/j.1365-2249.1994.tb06054.x.