血型相关碳水化合物抗原的表达与乳腺癌预后的关系
Association of expression of blood group-related carbohydrate antigens with prognosis in breast cancer.
作者信息
Narita T, Funahashi H, Satoh Y, Watanabe T, Sakamoto J, Takagi H
机构信息
Department of Surgery II, Nagoya University School of Medicine, Japan.
出版信息
Cancer. 1993 May 15;71(10):3044-53. doi: 10.1002/1097-0142(19930515)71:10<3044::aid-cncr2820711026>3.0.co;2-r.
BACKGROUND
It has been thought that carbohydrate antigens, especially Lewis (Le) blood group antigens, are cancer-related antigens.
METHODS
The authors conducted immunohistochemical studies to investigate the expression of seven different types of Le carbohydrate antigens in breast cancer tissue and their usefulness as an indicator of the degree of malignancy and as a prognostic factor.
RESULTS
When this expression was compared in the cancerous portion of 300 breast cancers and noncancerous mammary ductal epithelium in each of the patients, reduced expression of type 1 carbohydrate antigens and increased expression of type 2 carbohydrate antigens were found in the cancerous portions. No correlation was detected between the antigen expression and clinicopathologic factors. The prognosis of patients in whom type 2 carbohydrate antigens were increased in the cancerous portion, especially Lex (19.7% of patients) and sialyl Lex-i (20.3% of patients), was poorer than in patients in whom they were not increased (P < 0.01).
CONCLUSIONS
The relative expression of type 2 carbohydrate antigens in breast cancer tissue seems capable of serving as a prognostic factor.
背景
一直以来人们认为碳水化合物抗原，尤其是刘易斯（Le）血型抗原是癌症相关抗原。
方法
作者进行免疫组化研究，以调查七种不同类型的Le碳水化合物抗原在乳腺癌组织中的表达情况，以及它们作为恶性程度指标和预后因素的效用。
结果
当在每位患者的300例乳腺癌癌灶部分和非癌性乳腺导管上皮中比较这种表达时，发现癌灶部分1型碳水化合物抗原表达降低，2型碳水化合物抗原表达增加。未检测到抗原表达与临床病理因素之间的相关性。癌灶部分2型碳水化合物抗原增加的患者，尤其是Lex（占患者的19.7%）和唾液酸化Lex-i（占患者的20.3%），其预后比未增加的患者差（P<0.01）。
结论
乳腺癌组织中2型碳水化合物抗原的相对表达似乎可作为一种预后因素。
Zotero 插件