Asai S, Watanabe T, Sakamoto J, Kiriyama K, Ito K, Akiyama S, Takagi H
Department of Surgery II, Nagoya University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1994 Oct;95(10):753-62.
The immunohistochemical analysis using the monoclonal antibodies to the blood group antigens was performed on the tissues of 387 colorectal cancers and 307 normal colonic tissues, and the relation between expression of these antigens and prognosis of the patients with stage 2 was also investigated. La, Le(b), and CA 19-9 were used for type 1 antigens, and Le(x), Le(y), and Sialyl Le(x) for type 2, respectively. Expression of Ca 19-9 and Silyl Le(x) remarkably increased in cancers throughout the colorectum. Le(b) and Le(y) were expressed in only 0-17% of the normal distal colon, but in almost colonic tumors. Therefore CA 19-9 and Sialyl Le(x) are tumor-associated antigens in the whole colorectum, and Leb and Le(y) in the distal colon. Expression of CA 19-9 in primary tumor provided more prognostic information and risk of liver metastasis than other Lewis blood group antigens.
使用针对血型抗原的单克隆抗体对387例结直肠癌组织和307例正常结肠组织进行了免疫组织化学分析，并研究了这些抗原的表达与Ⅱ期患者预后之间的关系。分别使用La、Le(b)和CA 19-9作为1型抗原，Le(x)、Le(y)和唾液酸化Le(x)作为2型抗原。Ca 19-9和唾液酸化Le(x)在整个结直肠癌中的表达显著增加。Le(b)和Le(y)仅在0-17%的正常远端结肠中表达，但在几乎所有结肠肿瘤中均有表达。因此，CA 19-9和唾液酸化Le(x)是全结肠的肿瘤相关抗原，而Leb和Le(y)是远端结肠的肿瘤相关抗原。与其他Lewis血型抗原相比，原发肿瘤中CA 19-9的表达提供了更多的预后信息和肝转移风险。
