Fisher L A
Department of Pharmacology, College of Medicine, Arizona Health Sciences Center, Tucson 85724.
Ciba Found Symp. 1993;172:243-53; discussion 253-7. doi: 10.1002/9780470514368.ch12.
The physiological role of corticotropin-releasing factor (CRF) in mediating stress-induced activation of the pituitary-adrenal axis, together with the neuroanatomical distribution of immunoreactive CRF and CRF receptors, provides a compelling rationale for investigating actions of CRF within the central nervous system (CNS) on autonomic nervous outflow and cardiovascular function. Evidence is reviewed showing that CRF acts within the CNS to elicit stress-like patterns of autonomic nervous outflow and cardiovascular changes in conscious animals. In addition, blockade of CRF-mediated neurotransmission is demonstrated to alter the expression of stress-induced autonomic nervous and cardiovascular responses. Together, the anatomical, pharmacological and physiological data support the hypothesis that the autonomic nervous and cardiovascular responses to selected stressful stimuli may be mediated in part by CRF-containing neuronal pathways.
促肾上腺皮质激素释放因子（CRF）在介导应激诱导的垂体-肾上腺轴激活中的生理作用，以及免疫反应性CRF和CRF受体的神经解剖学分布，为研究CRF在中枢神经系统（CNS）内对自主神经流出和心血管功能的作用提供了令人信服的理论依据。本文综述了相关证据，表明CRF在中枢神经系统内发挥作用，在清醒动物中引发类似应激的自主神经流出模式和心血管变化。此外，已证明阻断CRF介导的神经传递会改变应激诱导的自主神经和心血管反应的表达。总之，解剖学、药理学和生理学数据支持这样的假说，即对特定应激刺激的自主神经和心血管反应可能部分由含CRF的神经元通路介导。
