Sanchez M R, Ross B, Rotterdam H, Salik J, Brodie R, Freedberg I M
Department of Dermatology, New York University Medical Center, NY 10016.
J Am Acad Dermatol. 1993 May;28(5 Pt 2):853-8. doi: 10.1016/0190-9622(93)70117-c.
A 65-year-old woman treated with etretinate for pityriasis rubra pilaris developed chronic active hepatitis. The elevated transaminases were noted 2 months after initiation of therapy and peaked 2 months after discontinuation of etretinate. The spectrum of liver toxicity induced by etretinate is reviewed. We suggest that reported cases of retinoid-induced liver disease can be divided into four distinct categories: nonspecific reactive hepatitis, acute hepatitis, chronic active hepatitis, and severe fibrosis or cirrhosis.
一名65岁女性因毛发红糠疹接受依曲替酯治疗后出现慢性活动性肝炎。治疗开始后2个月发现转氨酶升高，并在停用依曲替酯后2个月达到峰值。本文综述了依曲替酯引起的肝毒性谱。我们认为，已报道的维甲酸诱导的肝病病例可分为四个不同类别：非特异性反应性肝炎、急性肝炎、慢性活动性肝炎以及严重纤维化或肝硬化。
