Weiss V C, Layden T, Spinowitz A, Buys C M, Nemchausky B A, West D P, Emmons K M
Br J Dermatol. 1985 May;112(5):591-7. doi: 10.1111/j.1365-2133.1985.tb15269.x.
Acute hepatitis developed in a patient taking etretinate for severe psoriasis. Discontinuation of therapy was followed by progression of the histological changes to chronic active hepatitis, despite improvement of his clinical and laboratory status. This is the third reported case of chronic active hepatitis associated with etretinate therapy, and the second patient in our group of twenty-two etretinate-treated patients with severe psoriasis to develop clinically significant hepatic disease. Immunological evaluation revealed a marked increase in the patient's OKMI-staining population of peripheral mononuclear cells and augmentation of Con A-induced lymphocyte blastogenesis in the presence of etretinate.
一名因严重银屑病服用阿维A酯的患者发生了急性肝炎。尽管其临床和实验室指标有所改善，但停用该疗法后，组织学改变仍进展为慢性活动性肝炎。这是第三例报告的与阿维A酯治疗相关的慢性活动性肝炎病例，也是我们治疗的22例严重银屑病患者中第二例出现具有临床意义的肝脏疾病的患者。免疫学评估显示，该患者外周血单个核细胞OKM1染色群体显著增加，且在阿维A酯存在的情况下，刀豆蛋白A诱导的淋巴细胞增殖增强。
